The recommended dose of Linagliptin is 5 mg once daily and can be taken with or without food. If added with Metformin, the dose of Metformin should be maintained and Linaglip administered concomitantly. When used in combination with Sulfonylurea, a lower dose of Sulfonylurea, a lower dose of Sulfonylurea, a lower dose of Sulfonylurea may be considered to reduce the risk of hypoglycemia.