Metabolic: Metabolic side effects have included hypoglycemia, hyperlipidemia, hypertriglyceridemia and weight gain.
Hypersensitivity: Hypersensitivity side effects have included urticaria, angioedema, localized skin exfoliation, and bronchial hyperreactivity.
Respiratory: Respiratory side effects have included nasopharyngitis and cough. Side effects reported when linagliptin was used in combination with glimepiride and metformin include upper respiratory infection.
Musculoskeletal: Musculoskeletal side effects have included arthralgia, back pain and myalgia. Side effects reported when linagliptin was used in combination with glimepiride and metformin include pain in extremities.
Endocrine: Endocrine side effects have included pancreatitis.
Nervous system: Nervous system side effects have included headache.
Gastrointestinal: Gastrointestinal side effects reported include diarrhea. Side effects reported when linagliptin was added on to basal insulin therapy include constipation.
Genitourinary: Genitourinary side effects reported when linagliptin was used in combination with specific anti-diabetic agents include urinary tract infection.
Other: Increases in uric acid were reported more frequently in patients treated with linagliptin than placebo.