Generic Medicine Info
Indications and Dosage
Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia
Adult: 25 mg tid.
Elderly: Dose reductions may be necessary.
Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.
Special Precautions
May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido.
Potentially Fatal: Neuroleptic malignant syndrome.
Drug Interactions
Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.
Description: Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.
Absorption: Oral bioavailability is about 30%; peak plasma concentrations after about 3 hr.
Excretion: Mainly via urine. Plasma half-life: 9.7 hr (oral); 4.3 hr (IV).
Store at 15-30°C (59-86°F).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Levosulpiride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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