Levodropropizine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Cough

Adult: 60 mg up to tid at intervals of at least 6 hours. Dosage recommendations may vary among countries or individual products (refer to specific product guidelines).
Child: 2-12 years 1 mg/kg/dose up to tid at intervals of at least 6 hours. Max: 3 mg/kg daily. >12 years Same as adult dose. Dosage recommendations may vary among countries or individual products (refer to specific product guidelines).

Hepatic Impairment

Severe: Contraindicated.

Administration

Should be taken on an empty stomach. Take between meals.

Contraindications

Excessive mucous discharge or limited mucociliary function (e.g. Kartagener syndrome or bronchial ciliary dyskinesia). Severe hepatic impairment.

Special Precautions

Severe renal impairment. Children.

Adverse Reactions

Significant: Rarely, drowsiness, altered consciousness.
Cardiac disorders: Palpitations.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal distress, heartburn.
General disorders and administration site conditions: Fatigue.
Nervous system disorders: Dizziness, headache, numbness.

Patient Counseling Information

This drug may cause drowsiness or altered consciousness, if affected, do not drive or operate machinery.

Action

Description: Levodropropizine, the (-)-(S)-isomer of dropropizine, is a cough suppressant with peripheral action. It decreases the excitability of tracheobronchial receptors thus suppressing the cough reflex.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Bioavailability: >75%. Time to peak plasma concentration: 0.75 hours (range: 0.25-2 hours).
Distribution: Plasma protein binding: 11-14%.
Excretion: Via urine (35% as unchanged drug and metabolites). Elimination half-life: 2.3 ± 0.5 hours.

Chemical Structure

Storage

Store below 30°C. Protect from light.

MIMS Class

Cough & Cold Preparations

ATC Classification

R05DB27 - levodropropizine ; Belongs to the class of other cough suppressants.

References

Anon. Levodropropizine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/06/2021.

Buckingham R (ed). Dropropizine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/06/2021.

Levopront 30 mg/5 mL Syrup (Metro Pharma Philippines, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 07/06/2021.

Levosif Syrup (PT Ferron Par Pharmaceuticals). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 07/06/2021.

Disclaimer: This information is independently developed by MIMS based on Levodropropizine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com