Levocil Side Effects

Infusion: Gastro-intestinal symptoms may occur (gastric or abdominal symptoms, loss of appetite, nausea, vomiting and diarrhoea). The onset of diarrhoea, particularly if severe, persistent and/or bloody during or after treatment with Levocil I.V may less frequently indicate the appearance of pseudomembranous colitis. Suspicion of pseudomembranous colitis requires immediate cessation of administration and treatment with appropriate specific antibiotic therapy. Products inhibiting peristalsis are contraindicated in this clinical situation.
Disturbances of the nervous system e.g. Headache, dizziness, sleep disturbances, unsteady gait and tremor (disturbances of muscular co-ordination), numbness and tingling in the limbs (paraesthesia; visual and auditory disturbances of the senses of taste and smell, hallucinations, convulsions and psychotic reactions such as restlessness, agitation, anxiety, depression and confusion). In some cases these reactions have occurred already after the first dose. In the event of such adverse reactions, Levocil I.V must be discontinued immediately and the doctor informed.
Changes in the blood picture (leukopenia, eosinophilia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, haemolytic anaemia), hepatitis and transient increase in liver enzymes and/or bilirubin and in serum creatinine have been observed, interstitial nephritis and acute kidney failure may also occur.
Local irritation, pain and reddening at the injection site, and phlebitis have been observed.
Allergic manifestation may occur in particularly hypersensitivity reactions of the skin such as pruritis, rash, urticaria and vasculitis. Isolated cases of severe bullous eruptions such as Stevens-Johnson syndrome. Toxic epidermal necrolysis (Lyell's syndrome) and erythema exsudativum multiforme have been reported. Photosensitivity reactions (Skin reaction on exposure to strong sunlight and artificial UV rays) have been reported. There have been symptoms such as fever, allergy, pneumonitis, angioedema, hypotension and anaphylactic-like shock. In the event of such reactions, Levocil I.V should be discontinued immediately. Medical treatment (therapy for shock) is imperative.
Tendinitis (eg, Achilles tendon) is less frequently observed with quinolones and if it is suspected, treatment with Levocil I.V should be halted immediately and appropriate treatment (e.g. Immobilization) must be initiated for the affected tendon. Other musculoskeletal side effects such as arthralgia and myalgia have been less frequently observed and less frequent occurrences include: Tendon rupture (Achilles tendon) may occur within 48 hours of starting treatment and may be bilateral.
Muscular weakness which may be of special importance in patients within myasthenia gravis.
Isolated cases of rhabdomyolysis have been reported.
Hypoglycemia, especially in diabetics may occur.
Asthenia, fungal overgrowth and proliferation of other resistant microorganism may occur.
Fluoroquinolones are known to possibly trigger attacks of porphyria in patients suffering with porphyria.