Levocil Drug Interactions

Tablet: Since it has been reported that other quinolones (enoxacin, etc.) used in combination with nonsteroidal anti-inflammatory drugs of phenylacetic/propionic acid derivatives, such as fenbufen, may rarely cause convulsions, this product should be administered carefully.
Since antacids containing aluminium or magnesium and drugs containing iron may interfere with the absorption of Levofloxacin resulting in attenuation of the efficacy of Levofloxacin, it is recommended to refrain from using this product with such products.
Infusion: If the patient takes concomitantly other drugs, ask the doctor or pharmacist, whether they are one of the here mentioned drugs. This also applies to drugs, which were not prescribed by the doctor.
There are indications of a pronounced lowering of the cerebral seizure threshold when quinolones are given concurrently with other agents which lower the seizure threshold (e.g. Theophylline). This also applies to the concomitant administration of quinolones and fenbufen or non-steroidal antiphlogistics (drugs for the treatment of rheumatic diseases).
The elimination of (renal clearance) of Levofloxacin was slightly reduced by cimetidine and probenecid. However, these interactions are unlikely to be of clinical relevance.
Levofloxacin should be given carefully when it is co-administered with drugs that affect a certain mode of elimination (tubular secretion) such as probenecid and cimetidine. This applies especially to patients with impaired renal function.
The half life of cyclosporine was slightly increased when co-administered with levofloxacin.