Levocabastine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Nasal
Allergic rhinitis

Adult: Spray 0.05% suspension in each nostril bid; increase to 3-4 times daily if necessary.
Child: ≥9 yr: Spray 0.05% suspension in each nostril bid; increase to 3-4 times daily if necessary.

Ophthalmic
Allergic conjunctivitis

Adult: Instil 1 drop of 0.05% suspension in the affected eye(s) bid; increase to 3-4 times daily if necessary. Discontinue if there is no improvement within 3 days.
Child: ≥9 yr: Instil 1 drop of 0.05% suspension in the affected eye(s) bid; increase to 3-4 times daily if necessary. Discontinue if there is no improvement within 3 days.

Special Precautions

Pregnancy. Severe renal impairment (nasal).

Adverse Reactions

Ophthalmic: Transient stinging and burning of the eyes, urticaria, dyspnoea, drowsiness and headache. Nasal: Headache, nasal irritation, somnolence and fatigue.

Action

Description: Levocabastine, a cyclohexylpiperidine derivative, is a long-acting, potent selective histamine H₁-receptor antagonist.
Pharmacokinetics:
Absorption: Systemic availability: 60-80% (nasal); 30-60% (ocular).
Distribution: Protein-binding: 55%. Trace amounts detected in breast milk.
Excretion: Mainly via urine (70% as unchanged drug, 10% as metabolites); via faeces (20% as unchanged drug). 35-40 hr (elimination half-life).

Storage

Store at 15-30°C (59-86°F).

MIMS Class

Antihistamines & Antiallergics / Nasal Decongestants & Other Nasal Preparations / Other Eye Preparations

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