Hypersensitivity to the active substance or to any of the excipients.
Hypersensitivity (symptoms like asthma, rhinitis, angioedema or urticaria) to other NSAIDs including acetylsalicylic acid.
Severe heart failure.
Gastro-intestinal bleeding, cerebrovascular bleeding or other bleeding disorders.
History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy.
Active or history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of proven ulceration or bleeding).
Severe hepatic impairment.
Severe renal impairment (Serum creatinine > 700 μmol/l).
The third trimester of pregnancy.