Lafutidine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Gastric and duodenal ulcers, Stomal ulcers

Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient's age and symptoms.
Elderly: Dose reduction or increase in dosing interval may be needed.

Oral
Gastric mucosal lesions

Adult: 10 mg once daily, after evening meal or before sleeping. Adjust dose according to patient's age and symptoms.
Elderly: Dose reduction or increase in dosing interval may be needed.

Oral
Pre-anaesthetic medication

Adult: 10 mg before sleeping on the day before operation, and 10 mg 2 hr before introduction of anaesthetic on the day of operation.
Elderly: Dose reduction or increase in dosing interval may be needed.

Renal Impairment

Dose reduction or increase in dosing interval may be needed.

Hepatic Impairment

Dose reduction or increase in dosing interval may be needed.

Contraindications

Lactation.

Special Precautions

Hepatic and renal impairment. Elderly.

Adverse Reactions

Constipation, hyperuricaemia, increase in LFT and total bilirubin, gynaecomastia, anorexia, hallucinations.
Potentially Fatal: Anaphylactic reactions, blood dyscrasias (e.g. agranulocytosis, thrombocytopenia).

Action

Description: Lafutidine is a histamine H₂-antagonist with gastroprotective activity. It is used in the treatment of gastric ulcers and before general anaesthesia to reduce the incidence of aspiration pneumonia.
Pharmacokinetics:
Distribution: Protein binding: 88%.
Metabolism: Metabolised by CYP3A4 (mainly) and CYP2D6.
Excretion: Excreted in urine as unchanged drug and metabolites

MIMS Class

Antacids, Antireflux Agents & Antiulcerants

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