Ketanserin: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Hypertension

Adult: 20 mg bid; increase to 40 mg bid after 2-4 wk as necessary. May also be given via IV/IM admin.

Hepatic Impairment

Cirrhosis: Reduce dose or increase dosage interval. Severe hepatic impairment: A max of 20 mg bid is recommended.

Special Precautions

2nd or 3rd degree AV block. Patients predisposed to QT prolongation. May impair ability to drive or operate machinery.

Adverse Reactions

Sedation, fatigue, lightheadedness, dizziness, headache, dry mouth, GI disturbances, oedema, ventricular arrhythmias.

Drug Interactions

Hypotensive effects enhanced by diuretics and other antihypertensives.
Potentially Fatal: Increased risk of ventricular arrhythmias including torsade de pointes with antiarrhythmics or drugs that can cause hypokalaemia e.g. diuretics.

Action

Description: Ketanserin is a serotonin antagonist that binds to peripheral serotonin-2 (5HT₂) receptors resulting in inhibition of serotonin-induced vasoconstriction, bronchoconstriction and platelet aggregation.
Onset: 1-2 min (IV).
Duration: 30-60 min (IV).
Pharmacokinetics:
Absorption: Rapidly absorbed from the GIT (oral); bioavailability: about 50%. Peak plasma concentrations after 30-120 min.
Distribution: Protein-binding: 95%. May cross the placenta and some is present in breast milk.
Metabolism: Hepatic.
Excretion: Via urine (68% of an oral dose), via faeces (24%), mainly as metabolites.

MIMS Class

Other Antihypertensives

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