IV Administer dose ≤500 mg/500 mg over 20-30 min & >500 mg/500 mg over 40-60 min. Adult & adolescent 500 mg/500 mg every 6 hr or 1,000 mg/1,000 mg every 6 or 8 hr. Childn ≥1 yr 15 mg/15 mg or 25 mg/25 mg/kg/dose every 6 hr.
Present or history of allergies to any medicines including antibiotics. Present or history of colitis or any other GI disease; kidney or urinary problems including reduced kidney function; CNS disorders eg, localized tremor or epileptic seizures; liver problems. Patients on a controlled Na diet. May develop a +ve Coombs test. Concomitant use w/ valproic acid or Na valproate. May affect ability to drive or operate machinery. Pregnancy & lactation. Not recommended in childn <1 yr or w/ kidney problems.