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Aid in diagnostic procedures
Adult: Usual dose: 0.25-0.5 mg 5-10 minutes prior to the procedure.
Intravenous
Prophylaxis of cholinesterase inhibitor induced muscarinic adverse effects
Adult: Usual dose: 0.2 mg for each 1 mg of neostigmine or the equivalent dose of physostigmine or pyridostigmine given. Administer concomitantly with (in a separate syringe) or a few minutes before the anticholinesterase agent; if experiencing bradycardia, administer before the anticholinesterase agent.
Child: >2 years Same as adult dose.
Child: >2 years Same as adult dose.
Intravenous
Reversal of bradycardia
Adult: For the reversal of drug induced bradycardia during surgery: 0.125 mg, repeated as necessary.
Child: >2 years Same as adult dose.
Child: >2 years Same as adult dose.
Oral
Poisoning, anticholinesterase
Adult: Maintenance therapy following parenteral administration: 0.5-1 mg at intervals of several hours until signs and symptoms completely subside. Refer to specific product guideline or local treatment protocols for more detailed dosing information.
Oral
Biliary colic, Renal colic
Adult: For the symptomatic relief of cases, in combination with morphine or other narcotics: Conventional tab, orally disintegrating tab, oral solution, elixir: 0.125-0.25 mg 4 hourly or as needed. Max: 1.5 mg daily. Alternatively, as extended release tab: 0.375-0.75 mg 12 hourly. Max: 1.5 mg daily. Dosage may be adjusted based on patient condition and severity of symptoms. Dosage recommendation may vary among countries or individual products. Refer to specific product guidelines.
Child: <2 years Oral drops: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. 2-11 years Conventional tab: 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Oral solution: 0.03125-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Elixir: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. ≥12 years Conventional tab, extended release tab, orally disintegrating tab, oral solution, elixir: Same as adult dose.
Child: <2 years Oral drops: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. 2-11 years Conventional tab: 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Oral solution: 0.03125-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Elixir: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. ≥12 years Conventional tab, extended release tab, orally disintegrating tab, oral solution, elixir: Same as adult dose.
Oral
Gastrointestinal disorders
Adult: For the management of cases such as gastric secretion, visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps: Conventional tab, orally disintegrating tab, oral solution, elixir: 0.125-0.25 mg 4 hourly or as needed. Max: 1.5 mg daily. Alternatively, as extended release tab: 0.375-0.75 mg 12 hourly. Max: 1.5 mg daily. Dosage may be adjusted based on patient condition and severity of symptoms. Dosage recommendations may vary among individual products. Refer to specific product guidelines.
Child: <2 years Oral drops: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. 2-11 years Conventional tab: 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Oral solution: 0.03125-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Elixir: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. ≥12 years Conventional tab, orally disintegrating tab, extended release tab, oral solution, elixir: Same as adult dose.
Child: <2 years Oral drops: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. 2-11 years Conventional tab: 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Oral solution: 0.03125-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Elixir: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. ≥12 years Conventional tab, orally disintegrating tab, extended release tab, oral solution, elixir: Same as adult dose.
Oral
Irritable bowel syndrome, Peptic ulcer
Adult: As adjunctive therapy: Orally disintegrating tab: 0.125-0.25 mg 4 hourly or as needed. Max: 1.5 mg daily. Dosage may be adjusted based on patient condition and severity of symptoms.
Child: ≥12 years Same as adult dose.
Child: ≥12 years Same as adult dose.
Oral
Irritable bowel syndrome, Neurogenic bladder disorders, Neurogenic bowel, Parkinsonism, Peptic ulcer
Adult: As adjunctive therapy: Conventional tab, oral solution, elixir: 0.125-0.25 mg 4 hourly or as needed. Max: 1.5 mg daily. Alternatively, as extended release tab: 0.375-0.75 mg 12 hourly. Max: 1.5 mg daily. Dosage may be adjusted based on patient condition and severity of symptoms. Dosage recommendations may vary among individual products. Refer to specific product guidelines.
Child: <2 years Oral drops: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. 2-11 years Conventional tab: 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Oral solution: 0.03125-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Elixir: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. ≥12 years Conventional tab, orally disintegrating tab, extended release tab, oral solution, elixir: Same as adult dose.
Child: <2 years Oral drops: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. 2-11 years Conventional tab: 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Oral solution: 0.03125-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. Elixir: Dosage requirements may vary according to patient weight, refer to specific product guideline for dosing information. ≥12 years Conventional tab, orally disintegrating tab, extended release tab, oral solution, elixir: Same as adult dose.
Parenteral
Preoperative medication
Adult: Recommended dose: 0.005 mg/kg given via IV, IM, or SC inj 30-60 minutes prior to the anticipated time of induction of anaesthesia or at the time other pre-anaesthetic narcotics or sedatives are given.
Child: >2 years Same as adult dose.
Child: >2 years Same as adult dose.
Parenteral
Poisoning, anticholinesterase
Adult: Usual dose: 1-2 mg, preferably given via IV inj. Additional doses of 1 mg every 3-10 minutes may be given via IM or IV inj until muscarinic signs and symptoms subside and may be repeated if reappearance occurred. Doses up to 25 mg may be required during the 1st 24 hours of therapy. Transfer to oral medications for maintenance therapy.
Parenteral
Irritable bowel syndrome, Neurogenic bowel, Peptic ulcer
Adult: Usual dose: 0.25-0.5 mg given via IV, IM, or SC inj 2-4 times daily at 4-hour intervals. Dose is adjusted according to patient response and tolerance.
Sublingual
Irritable bowel syndrome, Neurogenic bladder disorders, Neurogenic bowel, Peptic ulcer
Adult: As adjunctive therapy: 0.125-0.25 mg 4 hourly or as needed. Max: 1.5 mg daily. Dosage may be adjusted based on patient condition and severity of symptoms.
Child: 2-<12 years 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. ≥12 years Same as adult dose.
Child: 2-<12 years 0.0625-0.125 mg 4 hourly or as needed. Max: 0.75 mg daily. ≥12 years Same as adult dose.
