Hydroquinone: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Hyperpigmentated skin conditions

Adult: As 2-4% preparation: Apply and rub in a thin layer to affected area bid, in the morning and evening. Discontinue if there is no improvement after 2 mth.

Incompatibility

Incompatible w/ alkalis, ferric salts and oxidizing agents.

Contraindications

Sunburn or depilatory usage.

Special Precautions

Pregnancy and lactation.

Adverse Reactions

Transient erythema, mild burning sensations, irritation, stinging, allergic dermatitis; dryness and fissuring of paranasal and infraorbital areas; ochronosis and colloid milium (chronic use).

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid unnecessary exposure to sunlight.

Monitoring Parameters

Test for skin sensitivity prior to use.

Action

Description: Hydroquinone is a topical depigmentating agent that produces a reversible depigmentation of the skin by inhibiting enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppressing melanocyte metabolic processes.

Chemical Structure

Storage

Store between 20-25°C. Protect from light.

MIMS Class

Other Dermatologicals

ATC Classification

D11AX11 - hydroquinone ; Belongs to the class of other dermatologicals.

References

Anon. Hydroquinone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/07/2016.

Buckingham R (ed). Hydroquinone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/07/2016.

Hydroquinone cream (Bi-Coastal Pharma International LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/07/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Hydroquinone (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/07/2016.

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