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Indications and Dosage
Parenteral
Facilitate SC/IM injections Adult: 1500 units directly added to the inj. Parenteral Adjunct in hypodermoclysis Adult: 1500 units for every 500-1000 ml of fluid for SC admin. Parenteral Aid in the diffusion of local anaesthetic in ophthalmology Adult: 15 units/ml of local anaesthetic solution. Parenteral Aid in the dispersal of extravasated fluids or blood Adult: 1500 units in 1 ml of water for inj or normal saline is injected into the affected area.
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Incompatibility
Parenteral:
Adjunct in hypodermoclysis: Physical incompatibility has been reported with heparin and adrenaline, frusemide, benzodiazepines and phenytoin. |
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Contraindications
Hypersensitivity, malignancy. Direct application to the cornea, reduction of swelling of bites or stings. Inj into or around infected area. IV admin; unexplained premature labour.
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Special Precautions
Impaired renal function. Infants, elderly. Patients with infections. Pregnancy, lactation.
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Adverse Reactions
Urticaria, occasional severe allergy.
Potentially Fatal: Hypersensitivity and anaphylaxis. |
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IM/Intradermal/Intraocular/Parenteral/SC: C
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Overdosage
Symptoms include hypotension, tachycardia, headache and generalised skin flushing. Other complications may include myocardial ischaemia and subsequent MI, cardiac arrhythmia and profound shock. Treatment is supportive and symptomatic.
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Drug Interactions
Action potentiated by urokinase especially in the treatment of MI. May increase absorption and toxicity of local anaesthetics. Heparin, salicylates and NSAIDs may inhibit the spreading action and efficacy of hyaluronidase.
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Action
Description: Hyaluronidase is an enzyme which reduces the viscosity of ground substance, thus making the tissues more permeable to injected fluids. It facilitates distribution and absorption of locally injected substances. It also promotes resorption of excess fluids and extravasated blood in the tissues.
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Storage
Refrigerate at 2-8°C.
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MIMS Class
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