Hetacillin

Hypersensitivity; infectious mononucleosis; lymphatic leukaemia; HIV infection.

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum K concentration, renal and hematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route.

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropaenia; thrombocytopaenia; CNS toxicity including convulsions; antibiotic-associated colitis. GI effects; pseudomembranous colitis; erythematous maculopapular erruptions.
Potentially Fatal: Anaphylaxis.

Probenecid prolongs T1/2 of hetacillin. Bacteriostatic drugs eg chloramphenicol, tetracyclines; other antibacterials; anticoagulants.

May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.

Description: Hetacillin is a β-lactam antibiotic which is converted in the body to ampicillin and has action similar to those of ampicillin.

Penicillins