HERBESSER, HERBESSER 60 and HERBESSER R100 are contraindicated in the following patients: Patients with severe congestive heart failure. [The symptoms of heart failure may be exacerbated.]; Patients with 2nd- or 3rd-degree atrioventricular block or sick sinus syndrome (continuous sinus bradycardia (less than 50 beats/minute), sinus arrest, sinoatrial block, etc.) [Excessive inhibition of sinus rhythm and cardiac conduction may occur.]; Patients with a history of hypersensitivity to any of the ingredients in the drug; Pregnant women or women who may possibly be pregnant, etc. [See Use during Pregnancy, Delivery or Lactation under Precautions.]