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Indications and Dosage
Intramuscular
Passive immunisation against hepatitis A infection Adult: Pre-exposure for travellers to endemic areas: For travel <3 mth, 0.02 ml/kg as a single dose; for travel >3 mth (each dose offers protection for 3-5 mth), 0.06 ml/kg/dose, may repeat every 5 mth if continued protection is required. Post-exposure (within 2 mth of exposure): 0.02 ml/kg as a single dose. Dose to be given by IM inj, into either the deltoid or gluteal muscles.
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Contraindications
Patients with IgA deficiency.
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Pain and erythema at inj site. Headache, malaise.
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Drug Interactions
May reduce the immunogenicity of live vaccines when used concurrently.
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Action
Description: Hepatitis A immunoglobulin is used for passive immunisation against hepatitis A infection. It provides short-term (1-2 mth) protection from hepatitis A. It is a sterile preparation of concentrated antibodies (immunoglobulins) made from pooled human plasma. It is usually used in persons planning to travel within 2-4 wk and who require immediate protection or for those with contraindications for vaccination.
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Storage
Store at 2-8°C.
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MIMS Class
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