Type 2 diabetes mellitus
Adult: Initially, 15 mg as a single daily dose, adjust by increments of 15 mg to a usual dose of 45-60 mg daily in 2 or 3 unequally divided doses, the largest dose being taken in the morning. Up to 60 mg/dose and 180 mg/day.
Indications and Dosage
Oral
Type 2 diabetes mellitus Adult: Initially, 15 mg as a single daily dose, adjust by increments of 15 mg to a usual dose of 45-60 mg daily in 2 or 3 unequally divided doses, the largest dose being taken in the morning. Up to 60 mg/dose and 180 mg/day.
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Administration
Should be taken with food. Small doses may be taken up to 30 min before breakfast. Large doses must be taken w/ meals.
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Contraindications
Type 1 diabetes mellitus; ketoacidosis; severe infection; trauma; other severe conditions where gliquidone is unlikely to control hyperglycaemia; pregnancy; lactation; porphyria; hypersensitivity; diabetic coma and pre-coma; prediabetic states; severe hepatic or renal impairment.
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Special Precautions
Elderly, debilitated or malnourished patients; adrenal or pituitary insufficiency. Monitor blood glucose concentrations carefully.
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Adverse Reactions
GI disturbances; metallic taste; skin rashes, pruritus, photosensitivity; facial flushing; hypoglycaemia; syndrome of inappropriate secretion of antidiuretic hormone; cholestatic jaundice; Stevens-Johnson syndrome; exfoliative dermatitis; erythema nodosum; increased appetite; wt gain; blood disorders.
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Drug Interactions
Increased hypoglycaemic effect by ACE inhibitors, alcohol, allopurinol, some analgesics, azole antifungals, cimetidine, clofibrate and related compounds, coumarin anticoagulants, halofenate, heparin, octreotide, ranitidine, sulfinpyrazone, sulfonamides, tricyclic antidepressants, thyroid hormones, MAOIs, chloramphenicol, tetracyclines. β-blockers increase hypoglycaemia and may mask warning signs. Diminished hypoglycaemic effect by adrenaline, aminoglutethimide, diazoxide, rifamycins, chlorpromazine, corticosteroids, oral contraceptives, hormones, thiazide diuretics.
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Lab Interference
Altered liver enzyme values.
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Action
Description: Gliquidone stimulates the production of organic insulin and normalizes the altered metabolic situation when diet alone cannot regulate this satisfactorily.
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MIMS Class
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