Adult: As immediate-release: Initially, 2.5-5 mg daily as a single dose. Adjust dose at intervals of several days in increments of 2.5-5 mg daily according to response. Doses >15 mg may be given in 2 divided doses. Max: 20 mg daily. As extended-release: Initially, 2.5-5 mg once daily, adjust dose according to response in increments of 5-10 mg once weekly. Max: 20 mg Elderly: Initially, 2.5 mg once daily, titrate dose by 2.5-5 mg daily at 1-2 weeks intervals. Maintenance dosing should be conservative.
Mild to moderate: As immediate release: Initially, 2.5 mg once daily, then elective titration up to 20 mg daily. Maintenance dosing should be conservative. As extended-release: 2.5 mg once daily. Severe: Contraindicated.
Mild to moderate: Initially, 2.5 mg once daily. Maintenance dosing should be conservative. Severe: Contraindicated.
immediate-release: Should be taken on an empty stomach. Take 30 min before meals. extended-release: Should be taken with food. Swallow whole, do not chew/crush/divide.
Hypersensitivity to glipizide, other sulfonylureas or sulfonamides. Type 1 diabetes mellitus, diabetic ketoacidosis with or without coma or history of ketoacidotic coma, severe thyroid impairment. Severe renal or hepatic impairment. Pre-existing pathologic or iatrogenic severe gastrointestinal narrowing (extended-release). Concomitant use with miconazole.
Patients with established atherosclerotic CV disease, prior allergic reactions to sulphonamides, G6PD deficiency, stress-related states. Mild to moderate renal and hepatic impairment. Elderly, debilitated and malnourished patients. Pregnancy and lactation.
This drug may cause dizziness, drowsiness, and visual disturbances, if affected, do not drive or operate machinery.
Monitor blood and urine glucose concentrations, glycosylated Hb, renal function, LFT, weight; signs and symptoms of hypoglycaemia.
Symptoms: Hypoglycaemia; faintness, confusion, sweating or shaking. Management: Mild hypoglycaemia may be treated with oral glucose or with any sugary food or drinks. For severe hypoglycaemia, administer glucagon or rapid IV inj of glucose 50% solution followed by continuous infusion of glucose 10% solution. Monitor patient for at least 48 hours.
Increased plasma concentration with fluconazole and voriconazole. Increased hypoglycaemic effect with NSAIDs (e.g. phenylbutazone), ACE inhibitors, MAOIs, cimetidine, chloramphenicol, probenecid, coumarins and fibrates. Potentially Fatal: Severe hypoglycaemia leading to coma with miconazole.
Increased hypoglycaemic action with alcohol.
Description: Glipizide stimulates insulin release from pancreatic ß-cells and reduces glucose output from the liver. It also increases insulin sensitivity at peripheral target sites. Duration: 12-24 hours. Pharmacokinetics: Absorption: Rapidly and completely absorbed from the gastrointestinal tract (immediate-release). Food delays absorption. Bioavailability: 90-100%. Time to peak plasma concentration: 1-3 hours; 6-12 hours (extended-release). Distribution: Plasma protein binding: 98-99%, primarily to albumin. Volume of distribution: 10-11 L. Metabolism: Metabolised in the liver by CYP2C19 to inactive metabolites. Excretion: Via urine (<10% as unchanged drug; 80% as metabolites); faeces (10%). Elimination half-life: 2-5 hours.
Immediate-release: Store below 25°C. Protect from light. Extended-release: Store between 20-25°C. Protect from moisture and humidity.
A10BB07 - glipizide ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
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