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Indications and Dosage
Oral
Endometriosis Adult: 2.5 mg twice wkly; the 1st dose is taken on the 1st day of the menstrual cycle with the 2nd dose taken 3 days later; thereafter the doses should be taken on the same 2 days of each wk, usually for a period of 6 mth. If a dose is missed: Take 2.5 mg as soon as possible and maintain original dose sequence; if 2 or more missed doses: Discontinue, restart on 1st day of new cycle after a -ve pregnancy test.
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Administration
May be taken with or without food.
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Contraindications
Metabolic and/or vascular disorders during previous oestrogen and/or progestogen therapy. Thromboembolic disorders; marked hepatic, cardiac or kidney dysfunction; undiagnosed genital bleeding, androgen-dependent tumors; pregnancy, lactation.
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Special Precautions
Conditions which may be adversely affected by fluid retention. History of thrombosis; childn and adolescents; diabetes mellitus, polycythemia. Nonhormonal contraception is recommended. withdraw in the event of androgenic effects. Monitor liver function during treatment.
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Adverse Reactions
Menstrual disturbances. Acne, oily skin, fluid retention, wt gain, hirsutism, voice change, headache, GI disturbances, altered libido, hot flushes, breast size reduction, nervousness, change in appetite, muscle cramp, depression, arthralgia, isolated cases of benign intracranial hypertension.
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Drug Interactions
Antiepileptic drugs, rifampicin, oral contraceptives.
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Lab Interference
Increased liver enzyme values.
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Action
Description: Gestrinone is a synthetic steroidal hormone which has androgenic, anti-estrogenic and antiprogestogenic properties.
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