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Indications and Dosage
Intravenous
Aid controlled ventilation, Muscle relaxant in general anaesthesia Adult: Test dose: 20 mg may be given before anesth to determine drug sensitivity. Initially, 80-120 mg via IV inj, further doses of 20-40 mg may be given as required.
Child: 1.5 mg/kg. Neonates: 600 mcg/kg. |
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Contraindications
Severe renal impairment. Hypersensitivity to iodine. Mysasthenia gravis.
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Special Precautions
Careful dose titration and monitoring of the degree of block are required to prevent overdosage.
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Adverse Reactions
Tachycardia, increased BP.
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Drug Interactions
Lidocaine, procainamide, quinidine, and verapamil may enhance the block. Clindamycin can prolong the action of muscle relaxants. Apnoea may be prolonged when used with polymyxins. Anticholinesterases or long-term treatment with corticosteroids may antagonise the action of gallamine.
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Action
Description: Gallamine triethiodide is a benzylisoquinolinium competitive neuromuscular blocker. It is used to produce muscle relaxation in general anaesthesia during surgical procedures and to aid controlled ventilation.
Pharmacokinetics: Distribution: Distributed throughout the body tissues after IV admin. Metabolism: Not metabolised. Excretion: Excreted as unchanged drug in the urine. |
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MIMS Class
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