Discontinue use 1-2 wk prior to cataract surgery. Syncope; intraoperative floppy iris syndrome. Perform digital rectal exam & determine PSA prior to treatment & at regular intervals. Severe renal impairment (CrCl <10 mL/min). Dizziness can occur which may affect ability to drive & use machines. Childn & adolescents.
Rise in plasma levels w/ cimetidine. Fall in plasma levels w/ furosemide. Elimination rate may be increased w/ diclofenac & warfarin. Potential hypotensive effects w/ other α1-adrenoceptor antagonists.