Fentanyl-Piramal

Fentanyl-Piramal Dosage/Direction for Use

fentanyl

Manufacturer:

Piramal Critical Care

Distributor:

Evercare Pharma
Full Prescribing Info
Dosage/Direction for Use
Dosage: The dosage of FENTANYL should be individualized according to age, body weight, physical status, underlying pathological condition, use of other drugs, and type of surgery and anesthesia.
To avoid bradycardia, it is recommended to administer a small intravenous dose of an anti-cholinergic just before anesthetic induction.
Use as an analgesic supplement to general anesthesia: Low dose: 2 mcg/kg.
FENTANYL in small doses is most useful for minor surgery.
Moderate dose: 2-20 mcg/kg.
Where surgery becomes more complicated, a larger dose will be required. The duration of activity is dependent on dosage.
High dose: 20-50 mcg/kg.
During major surgical procedures, in which surgery is longer, and during which the stress response would be detrimental to the well-being of the patient, doses of 20-50 mcg/kg of FENTANYL with nitrous oxide/oxygen have been shown to have an attenuating effect. When doses in this range have been used during surgery, post-operative ventilation and observation are essential in view of the possibility of extended post-operative respiratory depression.
Supplemental doses of 25-250 mcg (0.5-5 mL) should be tailored to the needs of the patient and to the anticipated time until completion of the operation.
Use as an anesthetic agent: When attenuation of the response to surgical stress is especially important, doses of 50-100 mcg/kg may be administered with oxygen and a muscle relaxant. This technique provides anesthesia without necessitating the use of additional anesthetic agents. In certain cases, doses up to 150 mcg/kg may be required to produce this anesthetic effect. FENTANYL has been used in this fashion for open heart surgery and certain other major surgical procedures in patients for whom protection of the myocardium from excess oxygen demand is particularly indicated.
Special populations: Pediatrics: For induction and maintenance in children aged 2-12 years, a dose of 2-3 mcg/kg is recommended.
Elderly and debilitated patients: As with other opioids, the initial dose should be reduced in the elderly (>65 years of age) and in debilitated patients. The effect of the initial dose should be taken into account in determining supplemental doses.
Obese patients: In obese patients there is a risk of overdosing if the dose is calculated based on body weight. Obese patients should be dosed based on estimated lean body mass rather than on body weight only.
Renal impairment: In patients with renal impairment reduced dosing of FENTANYL should be considered and these patients should be observed carefully for signs of fentanyl toxicity (see Pharmacology: Pharmacokinetics under Actions).
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