Fentanyl-Piramal

Fentanyl-Piramal

fentanyl

Manufacturer:

Piramal Critical Care

Distributor:

Evercare Pharma
Concise Prescribing Info
Contents
Fentanyl citrate
Indications/Uses
Opioid analgesic supplement in general or regional anesth. For administration w/ a neuroleptic as anesth premed, induction & as an adjunct in the maintenance of general & regional anesth. As anesth agent in major surgery.
Dosage/Direction for Use
Individualized dosage. Analgesic supplement to general anesth Low dose: 2 mcg/kg. Moderate dose: 2-20 mcg/kg. High dose: 20-50 mcg/kg. Supplemental dose: 25-250 mcg until completion of the operation. Anesth agent 50-100 mcg/kg may be administered w/ O2 & muscle relaxant. May be increased up to 150 mcg/kg. Childn 2-12 yr Induction & maintenance 2-3 mcg/kg.
Contraindications
Known intolerance to any of its components or other opioids.
Special Precautions
Discontinue if serotonin syndrome is suspected. Avoid rapid bolus inj in patients w/ compromised intracerebral compliance. Resp depression; muscle rigidity. May induce hypotension especially in hypovolemic patients & in higher incidence w/ neuroleptics. Patients on chronic opioid therapy or history of opioid abuse; w/ uncontrolled hypothyroidism, pulmonary disease, decreased resp reserve, alcoholism. Monitor for signs & symptoms of resp depression & profound sedation in concomitant use w/ CNS depressants. Concomitant use w/ serotonergic drugs eg, SSRIs & SNRIs & drugs which impair metabolism of serotonin (including MAOIs). Allow at least 24 hr after administration before driving or operating a machine. Impaired hepatic or renal function. Pregnancy. Breastfeeding is not recommended for 24 hr following administration. Elderly & debilitated patients.
Adverse Reactions
Sedation, dizziness, dyskinesia; visual disturbance; bradycardia, tachycardia, arrhythmia; hypotension, HTN, vein pain; apnea, bronchospasm, laryngospasm; nausea, vomiting; allergic dermatitis; muscle rigidity; post-op confusion, neurological anesth complication. Euphoric mood; headache; BP fluctuation, phlebitis; hiccups, hyperventilation; chills, hypothermia; post-op agitation, procedural complication, airway complication of anesth.
Drug Interactions
May potentiate resp depression w/ CNS depressants eg, barbiturates, benzodiazepines or related drugs, neuroleptics, general anesth & alcohol. Clearance may be decreased w/ CYP3A4 inhibitor. Reduced clearance w/ oral ritonavir. Exposure may be increased &/or prolonged w/ other potent or less potent CYP3A4 inhibitors eg, voriconazole or fluconazole. Discontinue MAOIs 2 wk prior to any surgical or anesth procedure. May increase risk of serotonin syndrome w/ serotonergic agent eg, SSRI, SNRI or MAOI. Decreased total plasma clearance & vol of distribution of etomidate. Reduced plasma clearance of midazolam.
MIMS Class
Analgesics (Opioid)
ATC Classification
N01AH01 - fentanyl ; Belongs to the class of opioid anesthetics. Used as general anesthetics.
Presentation/Packing
Form
Fentanyl-Piramal inj 50 mcg/mL
Packing/Price
2 mL x 10 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in