Etveza Description

Each vial contains: Recombinant Human Tumor Necrosis Factor-α Receptor II: IgG Fc Fusion Protein (rh TNFR:Fc) 25mg.
Etanercept the INN for Recombinant Human Tumor Necrosis Factor-α Receptor II: IgG Fc (rhTNFR: Fc) Fusion Protein for Injection is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system.
The Molecular Weight of the monomer is 63-77kDa and Dimer is 450kDa.
The Sequence of 15 Amino Acids at N-terminal is Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly.
Etanercept is a colorless or slightly yellow and transparent liquid when dissolved in water.
Excipients/Inactive Ingredients: Mannitol, Sucrose, Tromethamine.