Impaired absorption w/ drugs that reduce gastric acidity. Decreased bioavailability leading to reduced efficacy w/ potent CYP3A4 inducers eg, antibacterials (INH, rifabutin, rifampicin), anticonvulsants (carbamazepine, phenobarb, phenytoin), antivirals (efavirenz, nevirapine). Increased bioavailability w/ potent CYP3A4 inhibitors eg, antibacterials (ciprofloxacin, clarithromycin, erythromycin), antivirals (ritonavir-boosted darunavir & fosemprenavir, indinavir, ritonavir). Increased plasma conc by itraconazole & corresponding advice: Contraindicated: levacetylmethadol (levomethadyl), methadone; disopyramide, dofetilide, dronedarone, quinidine; halofantrine; astemizole, mizolastine, terfenadine; ergot alkaloids [eg, dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine)]; irinotecan; lurasidone, PO midazolam, pimozide, sertindole, triazolam; bepridil, felodipine; lercanidipine, nisoldipine; ivabradine, ranolazine; eplerenone; cisapride; lovastin, simvastatin; colchicine (in patients w/ renal or hepatic impairment). Not recommended: tamsulosin; fentanyl; rifabutin; rivaroxaban; carbamazepine; dasatinib, nilotinib, trabectedin; aliskiren; everolimus; salmeterol; vardenafil; colchicine. Use w/ caution: alfentanil, buprenorphine (IV & sublingual), oxycodone; digoxin; coumarins, cilostazol, dabigatran; repaglinide, saxagliptin; praziquantel; ebastine; eletriptan; bortezomib, busulphan, docetaxel, erlotinib, ixabepilone, lapatinib, trimetrexate, vinca alkaloids; alprazolam, aripiprazole, brotizolam, buspirone, haloperidol, midazolam IV, perospirone, quetiapine, ramelteon, risperidone; maraviroc, indinavir, ritonavir, saquinavir; nadolol; other dihydropyridines including verapamil; aprepitant, domperidone; budesonide, ciclesonide, ciclosporin, dexamethasone, fluticasone, methylprednisolone, rapamycin (sirolimus), tacrolimus, temsirolimus; atorvastatin; reboxetine; fesoterodine, imidafenacin, sildenafil, solifenacin, tadalafil, tolterodine; alitretinoin (oral formulations), cinacalcet, mozavaptan, tolvaptan.