Adult & adolescent ≥12 yr Erosive reflux oesophagitis 40 mg once daily for 4 wk. May give additional 4 wk treatment for patients in whom oesophagitis has not healed or who have persistent symptoms.
Long-term management of healed oesophagitis to prevent relapse 20 mg once daily.
Symptomatic treatment of GERD w/o oesophagitis 20 mg once daily.
Adult Eradication of H. pylori & healing of H. pylori-associated duodenal ulcer, & prevention of peptic ulcer relapse in patient w/ H. pylori-associated ulcer Combination therapy: Esomeprazole 20 mg bd w/ amoxicillin 1 g bd & clarithromycin 500 mg bd, for 7 days.
NSAID-induced gastric ulcer 20 mg once daily. Treatment duration: 4-8 wk.
Zollinger-Ellison syndrome Initially, 40 mg bd. Individually adjust dose & continue treatment as long clinically indicated.
Prolonged treatment after IV-induced prevention of peptic ulcer rebleeding 40 mg once daily for 4 wk after IV-induced prevention of peptic ulcer rebleeding.
Severe hepatic impairment Max: 20 mg.
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