Sign Out
Paroxysmal nocturnal haemoglobinuria
Adult: Initially, 600 mg once wkly for 4 wk, then increased to 900 mg once wkly for 1 wk and every 12-16 days thereafter, given via infusion over 25-45 min.
Child: 5-<10 kg: Initially, 300 mg once wkly for 2 wk, then every 3 wk thereafter; 10-<20 kg: Initially, 600 mg once wkly for 1 wk, then 300 mg once wkly for 1 wk, then every 2 wk thereafter; 20-<30 kg: Initially, 600 mg once wkly for 3 wk, then every 2 wk thereafter; 30-<40 kg: Initially, 600 mg once wkly for 2 wk, then increased to 900 mg once wkly for 1 wk, then every 2 wk thereafter; ≥40 kg: Same as adult dose. Doses are given via infusion over 1-4 hr.
Child: 5-<10 kg: Initially, 300 mg once wkly for 2 wk, then every 3 wk thereafter; 10-<20 kg: Initially, 600 mg once wkly for 1 wk, then 300 mg once wkly for 1 wk, then every 2 wk thereafter; 20-<30 kg: Initially, 600 mg once wkly for 3 wk, then every 2 wk thereafter; 30-<40 kg: Initially, 600 mg once wkly for 2 wk, then increased to 900 mg once wkly for 1 wk, then every 2 wk thereafter; ≥40 kg: Same as adult dose. Doses are given via infusion over 1-4 hr.
Intravenous
Haemolytic uraemic syndrome, atypical
Adult: Initially, 900 mg once wkly for 4 wk, then increased to 1,200 mg once wkly for 1 wk and every 12-16 days thereafter, given via infusion over 25-45 min. Combination therapy w/ plasmapheresis/plasma exchange (PE/PI) or w/ fresh frozen plasma infusion: Give supplemental doses per session based on the most recent dose (PE/PI: 300 mg if recent dose was 300 mg or 600 mg if recent dose was ≥600 mg; fresh frozen plasma: 300 mg if recent dose was ≥300 mg), w/in 1 hr after PE/PI or 1 hr before fresh frozen plasma infusion.
Child: 5-<10 kg: Initially, 300 mg once wkly for 2 wk, then every 3 wk thereafter; 10-<20 kg: Initially, 600 mg once wkly for 1 wk, then 300 mg once wkly for 1 wk, then every 2 wk thereafter; 20-<30 kg: Initially, 600 mg once wkly for 3 wk, then every 2 wk thereafter; 30-<40 kg: Initially, 600 mg once wkly for 2 wk, then increased to 900 mg once wkly for 1 wk, then every 2 wk thereafter; ≥40 kg: Same as adult dose. Doses are given via infusion over 1-4 hr. Combination therapy w/ plasmapheresis/plasma exchange (PE/PI) or w/ fresh frozen plasma infusion: Give supplemental doses per each session based on the most recent dose (PE/PI: 300 mg if recent dose was 300 mg or 600 mg if recent dose was ≥600 mg; fresh frozen plasma: 300 mg if recent dose was ≥300 mg), w/in 1 hr after PE/PI or 1 hr before fresh frozen plasma infusion.
Child: 5-<10 kg: Initially, 300 mg once wkly for 2 wk, then every 3 wk thereafter; 10-<20 kg: Initially, 600 mg once wkly for 1 wk, then 300 mg once wkly for 1 wk, then every 2 wk thereafter; 20-<30 kg: Initially, 600 mg once wkly for 3 wk, then every 2 wk thereafter; 30-<40 kg: Initially, 600 mg once wkly for 2 wk, then increased to 900 mg once wkly for 1 wk, then every 2 wk thereafter; ≥40 kg: Same as adult dose. Doses are given via infusion over 1-4 hr. Combination therapy w/ plasmapheresis/plasma exchange (PE/PI) or w/ fresh frozen plasma infusion: Give supplemental doses per each session based on the most recent dose (PE/PI: 300 mg if recent dose was 300 mg or 600 mg if recent dose was ≥600 mg; fresh frozen plasma: 300 mg if recent dose was ≥300 mg), w/in 1 hr after PE/PI or 1 hr before fresh frozen plasma infusion.
