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Modification in the dosage regimen may be needed in special populations, including elderly patients, and those with hepatic or renal dysfunction. Although psychomotor and sleep studies in healthy subjects in the laboratory may predict that an antihistamine does not cause drowsiness, the safety margin can be narrow enough to cause a central sedating effect during actual treatment. This might result from a patient's individual sensitivity, disease-induced sedation or drug dosages that are for various reasons relatively or absolutely larger (patient's weight, poor response, reduced drug clearance, interactions). Mild to even moderate sedation is not necessarily a major nuisance, particularly if stimulants are added to the regimen (eg, in perennial rhinitis).
Use in pregnancy & lactation: Reports of effect on pregnant women and nursing mothers are not available. Ebast should be used only if the potential benefit to the mother outweighs the potential risk to the foetus.
