Duocetz Overdosage

The clinical presentation of overdose may include the signs and symptoms of tramadol toxicity, paracetamol toxicity or both. The initial symptoms of tramadol overdosage may include respiratory depression and or seizures. The initial symptoms seen within the first 24 hours following a paracetamol overdose are: anorexia, nausea, vomiting, malaise, pallor or diaphoresis. An overdosage of Tramadol/Paracetamol Combination Tablet (37.5mg/325mg) may be a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended.
Tramadol: Acute overdosage with tramadol can be manifested by respiratory depression, somnolence progression to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, seizures, bradycardia, hypotension, cardiac arrest, and death.
Deaths due to overdose have been reported with abuse and misuse of tramadol. Review of case reports has indicated that the risk of fatal overdose is further increased when tramadol is abused concurrently with alcohol or other CNS depressants, including other opioids.
In the treatment of tramadol overdosage, primary attention should be given to the re-establishment of a patent airway and institution of assisted or controlled ventilation. Supportive measures (including oxygen and vasopressors) should be employed in the management of circulatory shock and pulmonary edema accompanying overdose is indicated. Cardiac arrest or arrhythmias may require cardiac massage or defibrillation.
While naloxone will reverse some, but not all, symptoms caused by overdosage with tramadol, the risk of seizures also increased with naloxone administration. In animals convulsions following the administration of toxic doses of Tramadol/Paracetamol Combination Tablet (37.5mg/325mg) could be suppressed with barbiturates or benzodiazepines but were increased with naloxone. Naloxone administration did not change the lethality of an overdose in mice.
Hemodialysis is not expected to be helped in an overdose because it removes less than 7% of the administered dose in a 4-hour dialysis period.
Paracetamol: Serious potential consequences of overdosage with paracetamol are hepatic centrilobular necrosis, leading to hepatic failure and death. Renal tubular necrosis, hypoglycemia and coagulation defects also may occur. Early symptoms following a potentially hepatotoxic overdose may include: nausea, vomiting, diaphoresis and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post ingestion.
Standard recommendations should be followed for the treatment of paracetamol overdose.