Drotaverine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Antispasmodic

Adult: 40-80 mg tid.
Child: 1-6 yr: 20 mg 3-4 times daiily; >6 yr: 40 mg tid.

Administration

May be taken with or without food.

Contraindications

Severe renal/hepatic/cardiac dysfunction. Porphyria.

Special Precautions

Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.

Adverse Reactions

Vertigo, nausea, vomiting, dry mouth.

Drug Interactions

May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

Action

Description: Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.

MIMS Class

Antispasmodics

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