Premedication Breast, non-small cell lung, gastric, & head & neck cancers Oral corticosteroid eg, dexamethasone 16 mg daily for 3 days starting 1 day prior to docetaxel administration.
Prostate cancer Oral dexamethasone 8 mg, 12 hr, 3 hr & 1 hr prior to docetaxel infusion in concurrent use w/ prednisone or prednisolone.
Adjuvant treatment of operable node-positive breast cancer 75 mg/m
2 1 hr after doxorubicin 50 mg/m
2 & cyclophosphamide 500 mg/m
2 every 3 wk for 6 cycles.
Locally advanced or metastatic breast cancer Monotherapy: 100 mg/m
2. 1st-line treatment: In combination w/ doxorubicin: 75 mg/m
2 w/ doxorubicin 50 mg/m
2; In combination w/ trastuzumab: 100 mg/m
2 every 3 wk w/ trastuzumab wkly; In combination w/ capecitabine: 75 mg/m
2 every 3 wk w/ capecitabine 1,250 mg/m
2 bd for 2 wk followed by 1-wk rest period.
Non-small cell lung cancer Chemotherapy naïve patients 75 mg/m
2 immediately followed by cisplatin 75 mg/m
2 over 30-60 min.
After failure of prior platinum-based chemotherapy 75 mg/m
2 as single agent.
Prostate cancer 75 mg/m
2 w/ oral prednisone or prednisolone 5 mg bd administered continuously.
Gastric adenocarcinoma 75 mg/m
2 as 1-hr infusion followed by cisplatin 75 mg/m
2 as 1-3 hr infusion (both on day 1 only), followed by 5-fluorouracil 750 mg/m
2 daily as 24-hr continuous infusion starting at end of cisplatin infusion for 5 days. Repeat every 3 wk.
Induction treatment of inoperable locally advanced squamous cell carcinoma of the head & neck (SCCHN) followed by radiotherapy (TAX 323) 75 mg/m
2 as 1-hr infusion followed by cisplatin 75 mg/m
2 over 1 hr on day 1, followed by 5-fluorouracil 750 mg/m
2 daily as continuous infusion for 5 days. Repeat every 3 wk for 4 cycles.
Induction treatment of locally advanced (technically unresectable, low probability of surgical cure, & aiming at organ preservation) SCCHN followed by chemotherapy (TAX 324) 75 mg/m
2 as 1-hr IV infusion on day 1 followed by cisplatin 100 mg/m
2 as 30 min-3 hr infusion, followed by 5-fluorouracil 1,000 mg/m
2 daily as continuous infusion from day 1-4. Repeat every 3 wk for 3 cycles.