Diopolol

Bisoprolol fumarate

HTN; angina pectoris.

HTN Initially, 2.5-5 mg once daily. May be increased to 10-20 mg once daily in patients who initially received 5 mg once daily. In patients whose BP is not adequately controlled, gradually increase to max of 20 mg once daily. Angina pectoris 10 mg once daily. Max: 20 mg daily. Severe renal impairment (GFR <20 & >5 mL/min) &/or advanced hepatic insufficiency Max: 10 mg once daily.

May be taken with or without food.

Hypersensitivity. Acute heart failure or in episodes of decompensated heart failure requiring IV inotropic therapy; cardiogenic shock; 2^nd or 3^rd degree AV block (w/o pacemaker); sick sinus syndrome; SA block; bradycardia; hypotension; severe bronchial asthma or COPD; late stages of peripheral arterial occlusive disease & Raynaud's syndrome; untreated phaeochromocytoma; metabolic acidosis.

Heart failure (initiate w/ special titration phase if to be used in chronic heart failure). Bronchospasm including bronchial asthma, obstructive airway disease; concomitantly give bronchodilating therapy in bronchial asthma or other chronic obstructive lung disease. Concomitant treatment w/ inhalation anaesth. DM w/ large fluctuations in blood glucose values; hypoglycaemia symptoms can be masked. Strict fasting; ongoing desensitisation therapy; 1st degree AV block; Prinzmetal's angina; peripheral occlusive disease. May increase sensitivity to allergens & severity of anaphylactic reactions. Psoriasis or history of psoriasis. Do not administer in patients w/ phaeochromocytoma until after α-receptor blockade. May mask symptoms of thyrotoxicosis. Do not w/draw abruptly in patients w/ ischaemic heart disease. Not recommended in combination w/ Ca antagonists, clonidine or MAOIs (except MAO-B inhibitors). Occasionally, dizziness or fatigue may occur; may affect ability to drive & operate machines. Pregnancy. Not recommended to breastfeed during treatment.

Tiredness, dizziness; depression; mental confusion, short-term memory loss; headache, somnolence, nightmares, insomnia. Shortness of breath, bradycardia; cold extremities, arterial insufficiency usually Raynaud type, palpitations, CHF, peripheral edema, syncope, chest pain, hypotension. Wheezing, dyspnoea. Diarrhea; nausea, dry mouth, gastric pain, constipation, flatulence, digestive tract disorders, heartburn. Pruritus, rash; fever w/ aching & sore throat, laryngospasm, resp distress. Peyronie's disease; musculoskeletal pain, blurred vision, decreased libido, tinnitus.

May produce excessive reduction of sympathetic activity w/ other β-blockers; closely monitor patients receiving catecholamine-depleting drugs, eg, reserpine or guanethidine. Discontinue use for several days before w/drawal of clonidine. Caution in concurrent use w/ myocardial depressants or AV conduction inhibitors (eg, verapamil & diltiazem) or antiarrhythmic agents (eg, disopyramide). Increased risk of bradycardia w/ digitalis glycosides. Increased metabolic clearance resulting in shortened elimination t_½ in concurrent use w/ rifampin. Unresponsiveness to epinephrine in patients w/ history of severe anaphylactic reactions.

Beta-Blockers

C07AB07 - bisoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.

POM