Each film coated tablet contains: Vitamin B1 B.P 100 mg, Vitamin B6 B.P 100 mg, Vitamin B12 B.P 100 mcg.
(CCL Pharmaceuticals Specifications).
Pharmacology: Dilconeurine tablet contains Thiamine (vitamin B1), pyridoxine (vitamin B6) and cyanocobalamin (vitamin B12). Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis. Cyanocobalamin is used to treat vitamin B12 deficiency in people with pernicious anemia and other conditions. Vitamin B6 helps the immune system to produce antibodies. Antibodies are needed to fight many diseases. Vitamin B6 helps to maintain normal nerve function and form red blood cells. The body uses it to help break down proteins. The more protein the patient eats, the more vitamin B6 is needed.
Thiamine, after conversion to Thiamine pyrophosphate, functions with adenosine triphosphate (ATP) in carbohydrate metabolism. Deficiencies result in beriberi, characterized by GI manifestations, peripheral neuropathy, and cerebral deficits.
Pharmacokinetics: Absorption: Thiamine is a water-soluble vitamin. It is absorbed by both diffusion and active transport mechanisms. Vitamin B12 is bound to intrinsic factor during transit through the stomach; separation occurs in the presence of calcium, and vitamin B12 enters the mucosal cells for absorption. Pyridoxine is absorbed by passive diffusion in the jejunum and to a lesser extent in the ileum.
Distribution: Thiamine is widely distributed in all tissues, with highest concentrations in liver, brain, kidney, and heart. When Thiamine intake exceeds needs, tissue stores increase more than 2 to 3 times. If intake is insufficient, tissues become depleted of their vitamin content.
Pyridoxine is stored mainly in liver with lesser amounts in muscle and brain.
Vitamin B12 is distributed and stored primarily in the liver and bone marrow. In the blood, it is bound to transcobalamin I & II.
Metabolism: Pyridoxine is metabolized in liver and converted to 4-pyridoxic acid metabolite.
Thiamine undergoes rapid metabolism. Thiamine + ATP → thiamine pyrophosphate (cocarboxylase) co-enzyme.
Elimination: Excess Thiamine is excreted in urine. Depletion of vitamin B1 occurs about 3 week with absence of Thiamine in diet. Pyridoxine metabolites are excreted in urine. Unbound vitamin B12 is rapidly eliminated in the urine.
Vitamin B1, B6, B12 deficiency leading to mono and polyneuropathy, peripheral neuropathy dementia, Beri-Beri etc.
Alcoholic polyneuropathy and Wernicke's encephalopathy.
Supportive treatment in trigeminal neuralgia.
One tablet daily.
For treatment during pregnancy, 1 tablet daily.
Hypersensitivity to cobalt, vitamin B12, or any component of these medications.
Deficiency: Single vitamin B1 deficiency is rare; suspect multiple vitamin deficiencies.
Wernicke’s encephalopathy: May occur or worsen suddenly in Thiamine-deficient patients given glucose. If deficiency is suspected, give Thiamine before or with dextrose-containing fluids.
Before using Dilconeurine: Some medical conditions may interact with Dilconeurine. Tell the doctor or pharmacist if the patient has any medical conditions, especially if any of the following applies: if the patient is pregnant, planning to become pregnant, or is breast-feeding; if the patient is taking any prescription or non-prescription medicine, herbal preparation, or dietary supplement; if the patient has allergies to medicines, foods, or other substances, any type of infection; iron or folic acid deficiency; kidney or liver disease; or if the patient is receiving any medication or treatment that affects bone marrow
Use in Pregnancy: Category A (Category C if used in doses greater than the RDA).
Use in Lactation: Vitamin B12 is excreted during lactation. Data is not available whether the thiamine is excreted in milk or not.
Pregnancy: Category A (Category C if used in doses greater than the RDA).
Lactation: Vitamin B12 is excreted during lactation. Data is not available whether the thiamine is excreted in milk or not.
Some MEDICINES MAY INTERACT with Pyridoxine (Vitamin B6). Tell the health care provider if the patient is taking any other medicines, especially any of the following: Hydantoins (eg., phenytoin) or levodopa because effectiveness may be decreased by Pyridoxine (Vitamin B6).
The patient should not use this medication if they are allergic to cobalt, or if they have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.
Store below 30ºC.
Protect from heat, sunlight & moisture.
A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.
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