Dilconeurine

Dilconeurine Mechanism of Action

Manufacturer:

CCL Pharma

Distributor:

Manawhari
Full Prescribing Info
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Pharmacology: Dilconeurine tablet contains Thiamine (vitamin B1), pyridoxine (vitamin B6) and cyanocobalamin (vitamin B12). Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis. Cyanocobalamin is used to treat vitamin B12 deficiency in people with pernicious anemia and other conditions. Vitamin B6 helps the immune system to produce antibodies. Antibodies are needed to fight many diseases. Vitamin B6 helps to maintain normal nerve function and form red blood cells. The body uses it to help break down proteins. The more protein the patient eats, the more vitamin B6 is needed.
Thiamine, after conversion to Thiamine pyrophosphate, functions with adenosine triphosphate (ATP) in carbohydrate metabolism. Deficiencies result in beriberi, characterized by GI manifestations, peripheral neuropathy, and cerebral deficits.
Pharmacokinetics: Absorption: Thiamine is a water-soluble vitamin. It is absorbed by both diffusion and active transport mechanisms. Vitamin B12 is bound to intrinsic factor during transit through the stomach; separation occurs in the presence of calcium, and vitamin B12 enters the mucosal cells for absorption. Pyridoxine is absorbed by passive diffusion in the jejunum and to a lesser extent in the ileum.
Distribution: Thiamine is widely distributed in all tissues, with highest concentrations in liver, brain, kidney, and heart. When Thiamine intake exceeds needs, tissue stores increase more than 2 to 3 times. If intake is insufficient, tissues become depleted of their vitamin content.
Pyridoxine is stored mainly in liver with lesser amounts in muscle and brain.
Vitamin B12 is distributed and stored primarily in the liver and bone marrow. In the blood, it is bound to transcobalamin I & II.
Metabolism: Pyridoxine is metabolized in liver and converted to 4-pyridoxic acid metabolite.
Thiamine undergoes rapid metabolism. Thiamine + ATP → thiamine pyrophosphate (cocarboxylase) co-enzyme.
Elimination: Excess Thiamine is excreted in urine. Depletion of vitamin B1 occurs about 3 week with absence of Thiamine in diet. Pyridoxine metabolites are excreted in urine. Unbound vitamin B12 is rapidly eliminated in the urine.
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