Some MEDICINES MAY INTERACT with Pyridoxine (Vitamin B6). Tell the health care provider if the patient is taking any other medicines, especially any of the following: Hydantoins (eg., phenytoin) or levodopa because effectiveness may be decreased by Pyridoxine (Vitamin B6).
The patient should not use this medication if they are allergic to cobalt, or if they have Leber's disease. Cyanocobalamin can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.