Hypersensitivity; anaphylactic/anaphylactoid reactions. Avoid concomitant use w/ NSAIDs (including cyclooxygenase-2 selective inhibitors). May precipitate bronchospasm in patients w/ or a history of resp disorders eg, bronchial asthma. Monitor patients w/ a history of HTN, mild to moderate CHF for fluid retention & oedema associated w/ NSAID therapy. Uncontrolled HTN, CHF, ischemic heart disease, peripheral arterial disease & cerebrovascular disease. Patients w/ risk factors for CV disease eg, HTN, hyperlipidaemia, DM, smoking. Potentially fatal GI bleeding, ulceration & perforation. Monitor and commence treatment on the lowest dose or consider combination therapy w/ protective agents in patients w/ history of ulceration, ulcerative colitis, Crohn's disease, bleeding, diathesis, haematological abnormalities, & in patients requiring low dose ASA or drugs likely to increase GI risk. Risk of aseptic meningitis in patients w/ SLE & mixed connective tissue disorders. Serious skin reactions eg, exfoliative dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis; discontinue use at 1st appearance of hypersensitivity reactions. May impair ability to drive or operate machinery. Monitor renal function in patients w/ renal & cardiac impairment, hepatic dysfunction, those taking diuretics & the elderly for potential dose-dependent reduction in prostaglandin formation & renal failure. Discontinue if abnormal liver function test persists or worsens, clinical signs or symptoms consistent w/ liver disease develop or other manifestations occur; closely monitor patients w/ mild to moderate hepatic impairment; hepatitis may occur w/o prodromal symptoms; may trigger attack in patients w/ hepatic porphyria. Not recommended in women of childbearing potential. Pregnancy & lactation. Increased frequency of AR, especially GI bleeding & perforation, which may be fatal in the elderly. Not recommended in childn.