Anaphylactic/anaphylactoid reactions can occur. May mask infection-signs &-symptoms. Na metabisulphate content may lead to isolated severe hypersensitivity reactions & bronchospasm. Potentially fatal, GI bleeding (haematemesis, melaena), ulceration or perforation; w/draw therapy if GI bleeding or ulceration occurs. Consider combination therapy w/ protective agents (eg, misoprostol or proton pump inhibitors) in patients w/ history of ulcer (particularly if complicated w/ haemorrhage or perforation, in the elderly, required of concomitant therapy w/ low-dose aspirin or agents increasing GI risk. Report any unusual abdominal symptoms (especially GI bleeding) in patients w/ GI toxicity history (particularly in the elderly). Close medical surveillance in patients w/ ulcerative colitis, or w/ Crohn's disease; patients w/ hepatic impairment. Liver enzymes may increase. Discontinue if abnormal liver function tests persist or worsen, clinical signs or symptoms consistent w/ liver disease develop or if other manifestations occur (eosinophilia, rash). Potential hepatitis w/o prodromal symptoms. Attacks may be triggered in patients w/ hepatic porphyria. Fluid retention & oedema in patients w/ cardiac or renal impairment, history of HTN, elderly, receiving concomitant treatment w/ diuretics or agents w/ significant renal-function impact, w/ substantial extracellular vol depletion from any course eg, pre- & post-op; monitor renal function. Very rare but potentially fatal, serious skin reactions including exfoliative dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis; highest risk appears during early course of therapy. Discontinue at 1st appearance of skin rash, mucosal lesions or any other hypersensitivity signs. Increased risk of aseptic meningitis in patients w/ SLE & mixed connective tissue disorders. Monitor patients w/ history of HTN &/or mild to moderate CHF for potential fluid retention & oedema. Increased risk of arterial thrombotic events w/ high-dose & long term therapy; treat only after careful consideration. Patients w/ uncontrolled HTN, CHF, established ischaemic heart disease peripheral arterial disease, &/or cerebrovascular disease; prior to initiation, patients w/ CV events risk factors (eg, HTN, hyperlipidaemia, DM, smoking). Monitor blood count during prolonged treatment. May reversibly inhibit platelet aggregation; carefully monitor patients w/ defects of haemostasis, bleeding diathesis or haematological abnormalities. Patients w/ asthma, seasonal allergic rhinitis, swelling of nasal mucosa (eg, nasal polyps), COPD or chronic resp tract infections (especially if linked to allergic rhinitis-like symptoms), reactions on NSAIDs eg, asthma exacerbations, Quincke's oedema or urticaria; w/ allergy to other substances eg, w/ skin reactions, pruritus or urticaria. May precipitate bronchospasm in patients suffering from or w/ previous history of bronchial asthma. Avoid concomitant use w/ systemic NSAIDs including cyclooxygenase-2 selective inhibitors. Concomitant therapy w/ medications which could increase risk of ulceration or bleeding eg, systemic corticosteroids, anticoagulants (eg, warfarin), SSRIs or anti-platelet agents. Not recommended in women attempting to conceive as it may impair fertility. Patients w/ low body wt. Elderly.