Cypon Overdosage

Overdosage of antihistamines, particularly in infants and young children, may produce hallucinations, CNS depression, convulsions, respiratory and cardiac arrest and death.
Antihistamine overdosage reactions may vary from CNS depression to stimulation especially in paediatric patients. Also, atropine-like signs and symptoms (dry mouth; fixed, dilated pupils; flushing, etc.) as well as GI symptoms may occur.
If vomiting has not occurred spontaneously, the patient should be induced to vomit with syrup of ipecac.
If the patient is unable to vomit, perform gastric lavage followed by activated charcoal. Isotonic or ½ isotonic saline is the lavage of choice. Precautions against aspiration must be taken especially in infants and children.
When life-threatening CNS signs and symptoms are present, IV physostigmine salicylate may be considered. Dosage and frequency of administration are dependent on age, clinical response and recurrence after response. Saline cathartics, as milk of magnesia, by osmosis draw water into the bowel and, therefore, are valuable for their action in rapid dilution of bowel content.
Stimulants should not be used.
Vasopressors may be used to treat hypotension. The oral LD₅₀ of cyproheptadine is 123 mg/kg and 295 mg/kg in the mouse and rat, respectively.