Cravit Drug Interactions

Antacid, Sucralfate, Metal Cations and Multivitamins: While the chelation by divalent cations is less marked than with other quinolones, concurrent administration of Cravit with antacids containing magnesium or aluminum, as well as sucralfate, metal cations eg, iron and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin resulting in systemic levels considerably lower than desired. These agents should be taken at least 2 hrs before or 2 hrs after levofloxacin administration.
Theophylline, Fenbufen, or Similar Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (Phenylacetic Acid/Propionic Acid Derivatives): No pharmacokinetic interactions of levofloxacin were found with theophylline in a clinical study. However, there are indications of a pronounced lowering of the cerebral seizure threshold when quinolones are given concurrently with other drugs that lower seizure threshold (eg, theophylline) or with fenbufen or similar NSAIDs.
Antidiabetic Agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. Therefore, careful monitoring of blood glucose is recommended when these agents are co-administered.
Anticoagulants (Warfarin and its Derivatives): Co-administration of warfarin and its derivatives has been reported that the effect of warfarin was potentiated (hepatic metabolism of warfarin may be inhibited, or free warfarin may be increased by competitive displacement from the protein-binding site) and therefore, prothrombin time prolonged.
Class IA and Class III Antiarrhythmics: Levofloxacin should be used with caution in patients receiving class IA antiarrhythmics (eg, quinidine sulfate and procainamide hydrochloride) and class III antiarrhythmics (eg, amiodarone HCl and sotalol HCl). Prolonged QT may occur.