Empirical Treatment for Community-Acquired Pneumonia: 500 or 750 mg is administered once daily.
Patients with Normal Renal Function: See Table 1.
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Patients with Impaired Renal Function: See Table 2.
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When only the serum creatinine is known, the following formula may be used to estimate creatinine clearance: See equation.
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The serum creatinine should represent a steady state of renal function.
Patients with Impaired Liver Function: No adjustment of dosage is required since levofloxacin is not metabolized to any relevant extent by liver and is mainly excreted by kidneys.
Elderly: No adjustment is required in the elderly, other than that imposed by consideration of renal function.