Colesevelam

Oral
Adjunct to type 2 diabetes mellitus, Hypercholesterolaemia

Should be taken with food.

History of bowel obstruction, serum triglyceride concentrations >500 mg/dL, history of hypertriglyceridemia-induced pancreatitis.

Patient w/ triglyceride concentration >300 mg/dL, dysphagia or swallowing disorders, gastroparesis or other GI motility disorders. Patient susceptible to vit K deficiency (e.g. malabsorption syndromes) or other fat-soluble vit. Patient who underwent major GI tract surgery and who may be at risk for bowel obstruction. Pregnancy and lactation.

Constipation, dyspepsia, nausea, accidental injury, asthenia, pharyngitis, flu-like syndrome, rhinitis, myalgia, hypoglycaemia. HTN, hypertriglyceridemia.

PO: B

Monitor lipid parameter, including serum triglyceride and non-HDL cholesterol concentrations prior to therapy and periodically thereafter.

Symptoms: Severe local GI effects (e.g. constipation). Management: Location and degree of obstruction, presence or absence of normal gut motility would determine treatment.

May decrease absorption of fat-soluble vit A, D, E and K. May interfere w/ anticoagulant effect of warfarin. May reduce serum concentration of ciclosporin, phenytoin, glibenclamide, ethinyl estradiol, norethindrone.

Description: Colesevelam, a nonabsorbable hydrogel, binds w/ bile acids in the intestine to form a nonabsorbable complex that is excreted in the faeces. This results in increased conversion of cholesterol to bile acids in the liver causing a compensatory increase in hepatic uptake of circulating LDL cholesterol.
Onset: Approx 2 wk.
Pharmacokinetics:
Absorption: Not absorbed from the GI tract.
Excretion: Via urine (0.05%).

Store at 25°C. Protect from moisture.

Dyslipidaemic Agents

Anon. Colesevelam. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/10/2014.

Buckingham R (ed). Colesevelam Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/10/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Colesevelam Hydrochloride. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 02/10/2014.

Welchol Film-Coated Tablet, Suspension (Daiichi Sankyo, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 02/10/2014.

Welchol Tablets. U.S. FDA. https://www.fda.gov/. Accessed 02/10/2014.