Clobetasone


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% oint/cream: Apply thinly and rub gently onto the affected area once daily or bid, gradually discontinued once control is achieved. Max duration of therapy: 4 wk.
Child: Same as adult dose. Max duration of therapy: 7 days.
Contraindications
Untreated cutaneous infections, rosacea, acne vulgaris, perioral dermatitis, pruritus w/o inflammation.
Special Precautions
Childn. Pregnancy and lactation.
Adverse Reactions
Significant: Contact dermatitis, skin irritation. Rarely, HPA axis suppression or hypercorticism (i.e. Cushing’s syndrome, hyperglycaemia, glycosuria).
CV: HTN.
Endocrine: Wt gain/obesity.
Musculoskeletal: Osteoporosis.
Ophthalmologic: Increased intraocular pressure, glaucoma, cataract.
Dermatologic: Exacerbation of eczema, skin atrophy, urticaria, rash, pruritus, erythema, acne, hypertrichosis, striae atrophicae, telangiectasia, mild depigmentation, perioral dermatitis.
Patient Counseling Information
Avoid contact w/ the face, eyes, scalp, genitals, groin, axilla, or between toes. Avoid use w/ occlusive dressing. Avoid abrupt withdrawal.
Monitoring Parameters
Monitor for adrenal insufficiency and hypothalamic-pituitary-adrenal (HPA) axis suppression.
Drug Interactions
Increased systemic exposure w/ CYP3A4 enzyme inhibitors (e.g. itraconazole, ritonavir). May diminish the antineoplastic effect of aldesleukin. May potentiate the hyperglycaemic effect of ceritinib. May diminish the therapeutic effect of corticorelin and hyaluronidase. May enhance the adverse/toxic effects of deferasirox.
Action
Description: Clobetasone is a glucocorticoid w/ anti-inflammatory, antipruritic, and vasoconstrictive effects. It induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release, and activity of endogenous chemical mediators of inflammation (e.g. histamine, kinins). Additionally, it decreases the density of mast cells, chemotaxis, and cytokine production.
Pharmacokinetics:
Absorption: May be systemically absorbed from intact healthy skin.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image
Clobetasone

Source: National Center for Biotechnology Information. PubChem Database. Clobetasone, CID=71387, https://pubchem.ncbi.nlm.nih.gov/compound/Clobetasone (accessed on Jan. 21, 2020)

Storage
Store between 15-25°C. Protect from light.
MIMS Class
Topical Corticosteroids
ATC Classification
D07AB01 - clobetasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
References
Anon. Clobetasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/03/2017.

Buckingham R (ed). Clobetasone Butyrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2017.

GlaxoSmithKline NZ Limited. Eumovate Cream 0.05% w/w data sheet 29 October 2012. Medsafe. http://www.medsafe.govt.nz/. Accessed 08/03/2017.

Joint Formulary Committee. Clobetasone Butyrate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2017.

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