The cytostatic agent has a more marked toxicity than is usually found in antineoplastic chemotherapy.
Renal toxicity, which is above-all cumulative, is severe and requires particular precautions during administration (see Dosage & Administration and Adverse Reactions).
Nausea, vomiting and diarrhoea often occur after administration of cisplatin (see Adverse Reactions). These symptoms disappear in most patients after 24 hours. Less serious nausea and anorexia may continue up to seven days after the treatment.
Nausea and vomiting may be intense and require adequate antiemetic treatment.
Prophylactic administration of an anti-emetic may be effective in alleviating or preventing nausea and vomiting.
The liquid loss caused by vomiting and diarrhoea must be compensated.
Close supervision must also be carried out with regard to ototoxicity, myelodepression and anaphylactic reactions (see Adverse Reactions).
Cisplatin has been shown to be mutagenic. It may also have an anti-fertility effect. Other anti-neoplastic substances have been shown to be carcinogenic and this possibility should be borne in mind in long term use of cisplatin.
Preparation of the intravenous solution: As with all other potentially toxic products, precautions are essential when handling the cisplatin solution. Skin lesions are possible in the event of accidental exposure to the product. It is advisable to wear gloves. In the event the cisplatin solution comes into contact with the skin or mucous membranes, wash the skin or mucous membranes vigorously with soap and water.
Conforming to the procedures appropriate for the manipulation and elimination of cytostatic agents is recommended.
Before administering the solution to the patient, verify the clarity of the solution and the absence of particles.