Cimetropium bromide: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Gastrointestinal tract spasm

Adult: 50 mg bid-tid. May also be given via rectal suppository.

Contraindications

Prostatic enlargement, paralytic ileus or pyloric stenosis.

Special Precautions

Caution when used in patients with diarrhoea or fever. Thyrotoxicosis, heart failure and in cardiac surgery. Children, elderly. Not advisable for use in angle-closure glaucoma.

Adverse Reactions

Mouth dryness, reduced bronchial secretions, pupil dilatation with loss of accommodation and photophobia. Skin flushing and dryness, transient bradycardia followed by tachycardia, with palpitations and arrhythmias, and micturition difficulty, as well as reduction in tone and motility of the GI tract resulting in constipation.

Drug Interactions

Effects may be enhanced when used with drugs with antimuscarinic properties e.g. amantadine, some antihistamines, phenothiazines and TCAs. May antagonise the GI effects of cisapride, domperidone and metoclopramide.

Action

Description: Cimetropium bromide is a quaternary ammonium antimuscarinic. It has been used as an antispasmodic in the treatment of GI disorders

MIMS Class

Antispasmodics

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