Acute malaria
Adult: As base: Initially, 600 mg followed by 300 mg 6-8 hr later on day 1. On days 2 and 3, single doses of 300 mg/day.
Child: Initially, 10 mg base/kg (max 600 mg base) followed by 5 mg base/kg (max 300 mg base) after 6 hrs. Single doses of 5 mg base/kg on days 2 and 3.
Child: Initially, 10 mg base/kg (max 600 mg base) followed by 5 mg base/kg (max 300 mg base) after 6 hrs. Single doses of 5 mg base/kg on days 2 and 3.
Oral
Hepatic amoebiasis
Adult: As base: 600 mg daily for 2 days then 300 mg daily for 2 or 3 wk given with emetine or dehydroemetine.
Child: 6 mg/kg daily. Max dose: 300 mg daily.
Child: 6 mg/kg daily. Max dose: 300 mg daily.
Oral
Rheumatoid arthritis
Adult: As base: 150 mg daily. Max: 2.5 mg/kg daily. Discontinue treatment if there is no improvement after 6 mth.
Child: Up to 3 mg/kg/day. Discontinue treatment if there is no improvement after 6 mth.
Child: Up to 3 mg/kg/day. Discontinue treatment if there is no improvement after 6 mth.
Oral
Discoid lupus erythematosus, Systemic lupus erythematosus
Adult: As base: Initially, 150 mg once daily, reduce gradually after maximal response. Max dose: 2.5 mg/kg daily.
Child: 3 mg/kg daily.
Child: 3 mg/kg daily.
Oral
Prophylaxis of malaria
Adult: As chloroquine base: 300 mg once weekly preferably same day each week, starting 1 week before exposure, continuing throughout only on a weekly basis and for at least 4 weeks after exposure.
Child: As chloroquine base: 5 mg/kg weekly, starting 1 week before exposure, continuing throughout only on a weekly basis and for at least 4 weeks after exposure.
Child: As chloroquine base: 5 mg/kg weekly, starting 1 week before exposure, continuing throughout only on a weekly basis and for at least 4 weeks after exposure.