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Indications and Dosage
Oral
Susceptible infections Adult: 500 mg bid.
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Contraindications
Hypersensitivity to cephalosporins.
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Special Precautions
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and hematologic status. Pregnancy, lactation.
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Adverse Reactions
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; pseudomembranous colitis; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
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Drug Interactions
Renal excretion delayed by probenecid. Decreases contraceptive effect of estrogen-containing oral contraceptives.
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Lab Interference
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
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Action
Description: Cefatrizine inhibits final cross-linking stage of peptidoglycan production thus inhibiting bacterial cell wall synthesis. It has excellent activity against gram-positive cocci except enterococci at minimal inhibitory concentrations <1 mcg/ml.
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MIMS Class
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