Appropriate dosage reduction may be necessary in patients with major kidney failure or severe liver failure.
Use in pregnancy: There is insufficient evidence to recommend the use of trimetazidine in pregnancy. Animal studies do not reveal any teratogenic effect.
Use in lactation: There is no information on the secretion of trimetazidine into breast milk. However, breastfeeding should be discontinued if the use of trimetazidine is considered essential.
Use in children: There is no experience with trimetazidine in children.