Adults: The recommended initial dose of ranolazine is 500 mg twice daily, according to the patient's response, further titrated to a recommended maximum dose of 750 mg twice daily.
If a patient experiences treatment-related adverse events (e.g. dizziness, nausea, or vomiting), down-titration of ranolazine to 375 mg twice daily may be required. If symptoms do not resolve after dose reduction, treatment should be discontinued.