In patients with an activated renin-angiotensin system eg, volume- and/or salt-depleted patients (eg, those being treated with diuretics), symptomatic hypotension may occur. These conditions should be corrected prior to administration of candesartan cilexetil. If hypotension occurs, the patient should be placed in the supine position and if necessary, given an IV infusion of normal saline. A transient hypotensive response is not a contraindication to further treatment, which can usually be continued without difficulty once the blood pressure has stabilized.
Use in pregnancy & lactation: Strictly not to be used during pregnancy. Drugs that can act directly on the renin-angiotensin system can cause fetal and neonatal morbidity and death when administered to pregnant women. When pregnancy is detected, candesartan cilexetil should be discontinued as soon as possible.
Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue candesartan, taking into account the importance of candesartan to the mother.